Measurement of drugs and their metabolites in biological fluids is the foundation of both therapeutic drug monitoring (TDM) and toxicology. Each discipline depends on accurate identification and quantification if the measurements are to be useful. The LC-MS/MS is pervasive in the large laboratories and increasingly so in the mid-tier toxicology and clinical settings because of its robustness, versatility and economics. Now, forward-looking laboratories are adopting the LDTD-MS/MS configuration because LDTD further increases throughput, as well as drives down costs sample-to-sample basis.
Given the limitations of immunoassays, most labs use a two-step process, starting with a qualitative screen, and follow with a confirmation to identify the individual drugs or compounds.
The OraSure Intercept® oral fluid drug test is used for saliva collection in the clinical setting. Oral fluid sampling provides an accurate and fast sampling method for many drugs of abuse. The combination of the oral fluid extraction procedure with the analysis speed of the LDTD-MS/MS is an ideal solution in high-throughput drug analysis. Several posters have been developed to prove just that – visit the LDTD database to see for yourself.