The pharmaceutical drug discovery and development lifecycle averages in excess of 10 years, and over $1 billion dollars to bring a drug to market. Assessment of physiochemical and pharmacological properties is now conducted at very early stages of drug discovery for the purpose of accelerating the conversion of hits and leads into qualified development candidates.
The Laser Diode Thermal Desorption (LDTD®) ion source is the best high-throughput analysis tool, used in early stages of drug discovery. LDTD has been adopted by ½ of the top 10 pharmaceutical firms worldwide.
Through Overbrook Scientific, leading global pharmaceutical firms like Abbott, Novartis and Sanofi use LDTD in the drug discovery process. This involves large sample sets, making a high-throughput approach desirable. By using the LDTD for ADMET studies, an analysis every 9 seconds dramatically increases throughput compared to current LC-MS/MS method of analysis.