CLINICAL DOCUMENTS

Laser Diode Thermal Desorption Application Notes

Clinical

Measurement of drugs and their metabolites in biological fluids is the foundation of both therapeutic drug monitoring (TDM) and toxicology. Each discipline depends on accurate identification and quantification if the measurements are to be useful. Immunosuppressant testing, Vitamin D and testosterone are a few of the most common tests conducted.

Vitamin D testing is prevalent as well, and for good reason. According to the National Center for Health Statistics, as many as 36% of Americans are low in vitamin D levels, with 40% of infants and toddlers testing below the optimal blood threshold level.

Key Parameters for a Good Liquid Transfer to Lazwell Plates

KEYWORDS:

  • Lazwell
  • LDTD
  • Liquid Transfer


Fast Analysis of Total Vitamin C in Plasma Using the LDTD-MS/MS Technique

KEYWORDS: 

  • LDTD-MS/MS


Hydroxychloroquine and Chloroquine Therapeutic Drug Monitoring in Blood at 8 seconds per Sample Using the LDTD-MS/MS Technique

KEYWORDS:

  • Drugs
  • LDTD-MS/MS

Antiepileptic Drugs Monitoring in Plasma using the LDTD-MS/MS Technique

KEYWORDS:

  • Drugs
  • LDTD-MS/MS


SAMHSA Drug Panel Screening in Oral Fluid: Development of a Screening Method at 8 Seconds per Sample Using LDTD-MS/MS

KEYWORDS:

  • Oral fluid
  • LDTD-MS/MS

Development of a Screening Method for 11-nor-9-carboxy-delta-tetrahydrocannabinol Drugs in Hair Using LDTD-MS3 at 8 Seconds per Sample

KEYWORDS:

  • Drugs
  • LDTD-MS3


Analysis of Serotonin in Serum as Biomarker of Clinical Disorders at 8 seconds per Sample using the LDTD-MS/MS Technique

KEYWORDS:

  • Serotonin
  • LDTD-MS/MS

Analysis of Total Vitamin C in Plasma: Vitamin C Quantification in Plasma at 9 Seconds per Sample Using Luxon Ion Source®

KEYWORDS:

  • High-throughput
  • Plasma
  • LDTD-MS/MS


High-Throughput Screening in Hair for Drugs: Screening of Drugs in Hair at 9 Seconds per Sample Using LUXON-MS/MS

KEYWORDS:

  • High-throughput
  • Hair
  • Drugs
  • Luxon-MS/MS 

Analysis of Urine Biomarker for Alcohol Consumption: Screening of ETG in Urine at 9 Seconds per Sample Using LUXON-MS/MS

KEYWORDS:

  • High-throughput
  • Urine
  • Luxon-MS/MS 


Analysis of Serotonin in Serum as a Biomarker of Clinical Disorders: Serotonin Quantification in Serum at 8 Seconds per Sample Using LUXON-MS/MS

KEYWORDS:

  • High-throughput
  • Urine
  • Luxon-MS/MS 

Analysis of Urine Biomarker for Toluene, Xylene and Styrene Exposure: Biomarker Screening in Urine at 8 Seconds per Sample Using LUXON-MS/MS

KEYWORDS:

  • High-throughput
  • Urine
  • Luxon-MS/MS 


Analysis of Total Vitamin C in Plasma:Vitamin C Quantification in Plasma at 9 Seconds per Sample Using Luxon Ion Source®

 

  • Partnership:
  • Molecules: 
  • Matrix:
  • Extraction Method:
  • Instrumentation: Luxon-MS/MS
  • No. Code: 2106

 

Analysis of Serotonin in Serum as a Biomarker of Clinical Disorders: Serotonin Quantification in Serum at 8 Seconds per Sample Using LUXON-MS/MS

 

  • Partnership: N/A
  • Molecules: Serotonin
  • Matrix: Serum
  • Extraction Method:  
  • Instrumentation: Luxon-MS/MS
  • No. Code: AN-2102

 

Hydroxychloroquine and Chloroquine Therapeutic Drug Monitoring in Blood at 8 Seconds per Sample Using Luxon-MS/MS

  • Partnership: None
  • Molecules: 
  • Matrix: Whole Blood
  • Extraction Method: NA
  • Instrumentation: Luxon-MS/MS
  • No. Code: AN-2007A

    Learn How to Analyze 25 Hydroxy-Vitamin D Metabolites Analysis in 9 Seconds Using LDTD-MS/MS

     

    • Partnership: N/A
    • Molecules: 25-OH-D2/D3
    • Matrix: Serum
    • Extraction Method:  
    • Instrumentation: Luxon-MS/MS
    • No. Code: 2005

     

    AN-1807 High-Throughput Analysis of Neuroleptics Drugs in Plasmas Using Luxon Ion Source

    • Partnership: None
    • Molecules: Norquetiapine, Clozapine, Desmethylclozapine, 9 - Hydroxyrisperidone, Aripiprazole
    • Matrix: Plasma
    • Extraction Method: 
    • Instrumentation: MS/MS
    • No. Code:1807

      Hematocrit Effect: Does It Influence the Analysis of Plasma Samples or Is It Just a DBS Concern?

      • Partnership: --
      • Molecules:
      • Matrix: Blood
      • Extraction Method: Liquid-Liquid extraction of plasma, DBS card extract, DBS in tips extract
      • Instrumentation: LDTD
      • No. Code:

        Urine and Serum Ultra-Rapid Analysis of Flakka (alpha-PVP) in 9 Seconds per Sample by LDTD-MS/MS

        • Partnership: Universite Laval
        • Molecules: Synthetic cathinone (Flakka)
        • Matrix: Urine and serum
        • Extraction Method: Liquid Liquid Extraction (LLE)
        • Instrumentation: SCIEX Qtrap 5500
        • No. Code:

          LDTD-MS/MS Method for Quantitative Analysis of Four Immunosuppressant Drugs in Whole Blood and Cost Analysis Comparison to LC-MS/MS

           

          • Partnership: ARUP Institute for Clinical and Experimental Pathology; University of Utah Health Sciences Center, Department of Pathology
          • Molecules: Immunosuppressants
          • Matrix: Whole blood
          • Extraction Method: Solid phase extraction (SPE)
          • Instrumentation: SCIEX 5500
          • No. Code:

           

          Quantification of Tenoflovir and Emtricitabine in Human Plasma Using High Throughput LDTD-MS/MS

          • Partnership: Universite Laval
          • Molecules: Tenofovir, Emtricitabine
          • Matrix: Human plasma
          • Extraction Method: SCX SPE cartridges and quick derivation using TMPAH
          • Instrumentation: SCIEX 5500 QTRAP
          • No. Code:

            Ultra-Fast Quantification of Antidepressants in Urine at 9 Seconds per Sample Using LDTD-MS/MS

            • Partnership: Universite Laval
            • Molecules: 7 antidepressants
            • Matrix: Urine
            • Extraction Method: Liquid-Lquid Extraction (LLE)
            • Instrumentation: SCIEX 5500 QTRAP
            • No. Code:

              Meconium Targeted Drug Screening in 9 Seconds per Sample Using LDTD-MS/MS

               

              • Partnership: ARUP Institute for Clinical and Experimental Pathology (Utah, USA)
              • Molecules: 26 drugs of abuse - including amphetamine, MDMA, etc.
              • Matrix: Mecondium
              • Extraction Method: Liquid Liquid Extraction (LLE)
              • Instrumentation: SCIEX 5500 QTRAP
              • No. Code:

               

              Meconium Targeted Drug Screening in 9 Seconds per Sample Using LDTD-MS/MS

               

              • Partnership: ARUP Institute for Clinical & Experimental Pathology, and University of Utah, Department of Pathology
              • Molecules: 26 drugs of abuse
              • Matrix: Meconium
              • Extraction Method: Liquid-Liquid
              • Instrumentation: Sciex 5500 QTrap
              • No. Code:

               

              Ultra-Fast Quantitative Analysis of Immunosuppressants in Dried Blood Spots Using LDTD Coupled to Tandem Mass Spectrometry

              • Partnership: None
              • Molecules: Cyclosporin A, Tacrolimus, Sirolimus, Everolimus
              • Matrix: DBS
              • Extraction Method:
              • Instrumentation:
              • No. Code: n/a

                Targeted Screening for Drugs of Abuse Using LDTD and Mass Spectrometry

                • Partnership: none
                • Molecules: Amphetamine, Methamphetamine, MDEA and MDMA
                • Matrix: Urine
                • Extraction Method: Liquid-liquid Extration (LLE)
                • Instrumentation: Sciex 5500 QTrap
                • No. Code:

                  Fate of Anti-inflammatory Drug Diclofenac in Municipal Wastewater Treatment Plant: Quantification Using LDTD Coupled with Tandem Mass Spectrometry

                  • Partnership: INRS-FTE University du Quebec (Quebec, Canada), C02 Solutions Inc. (Quebec, Canada), University of Nebraska-Lincoln (Lincoln, NE)
                  • Molecules: Diclofenac
                  • Matrix: Wastewater
                  • Extraction Method: SPE using C 18 cartridges
                  • Instrumentation: Thermo Vantage mass spectrometer
                  • No. Code: 307

                    Total Cholesterol and HDL Cross Validation Between High Throughput LDTD-MS/MS Method and Reference Enzymatic Technique Used in Clinical Laboratory

                    • Partnership: n/a
                    • Molecules: Cholesterol and HDL
                    • Matrix: Serum
                    • Extraction Method: Specific HDL separation, saponification reaction and LLE for cholesterol
                    • Instrumentation:
                    • No. Code: 329

                      Determination of Testosterone in Serum by Automated Sample Preparation and Ultra-Fast LDTD-DMS-MS-MS in a Cross Validation Study with Real Patient Samples

                      • Partnership: Tecan Group
                      • Molecules: Testosterone
                      • Matrix: Serum
                      • Extraction Method:
                      • Instrumentation: Sciex 5500 Qtrap with Selexion (DMS)
                      • No. Code:

                        HDL and Total Cholesterol Analysis by LDTD-MS/MS in 7 Seconds per Sample

                        • Partnership: N/A
                        • Molecules: Cholesterol
                        • Matrix: Seum
                        • Extraction Method: Saponification reaction and LLE
                        • Instrumentation: Waters Xevo TQ MS
                        • No. Code:

                          Total Cholesterol Analysis in Plasma at 7 Seconds per Sample Using LDTD-MS/MS

                           

                          • Partnership: Universite Laval Quebec
                          • Molecules: Cholesterol
                          • Matrix: Plasma
                          • Extraction Method: LLE
                          • Instrumentation: Waters Xevo TQ
                          • No. Code: THP411

                           

                          Method Validation of 12 Benzodiazepines by LDTD-MS/MS Analysis in 6 Seconds per Sample with Correlative Data from LC-MS/MS for 200 Real Patient Urine Samples

                          • Partnership: n/a
                          • Molecules: 12 benzodiazepines with similar chemical structures and molecular weight
                          • Matrix: Human urine
                          • Extraction Method: Sample hydrolysis, Solid phase extraction (SPE) and Liquid-liquid extraction (LLE)
                          • Instrumentation: AB Sciex Qtrap 5500
                          • No. Code: n/a

                            Selectivity Enhancement in High Throughput Analysis of Testosterone

                            • Partnership:
                            • Molecules: Testosterone
                            • Matrix:
                            • Extraction Method: Liquid-liquid extraction
                            • Instrumentation: AB Sciex Qtrap 5500 system with SelexION
                            • No. Code: MP 49

                              High-Throughput Analysis of Cocaine in Hair Samples using LDTD Combined with Mass Spectrometry

                              • Partnership: Omega Laboratories, Inc.
                              • Molecules: Cocaine
                              • Matrix: Hair
                              • Extraction Method: Liquid-liquid extraction
                              • Instrumentation: Thermo Vantage Mass spectrometer
                              • No. Code:

                              Fast and Selective Quantification of Testosterone in Plasma using LDTD-Qtrap 5500 SelexION System

                              • Partnership: None
                              • Molecules: Testosterone
                              • Matrix: Human Plasma
                              • Extraction Method: Liquid-Liquid
                              • Instrumentation: AB Sciex Qtrap 5500 with SelexION
                              • No. Code: 1220

                                Confirmation of Cotinine in Human Plasma and Analysis by LDTD–MS/MS

                                • Partnership: None
                                • Molecules: Cotinine
                                • Matrix: Human Plasma
                                • Extraction Method: Liquid-Liquid
                                • Instrumentation: AbSciex TripleTOF 5600
                                • No. Code: 1213

                                LDTD-MS/MS Method Validation According to FDA Regulation

                                • Partnership: None
                                • Molecules: Dextromethorphan
                                • Matrix: Human Plasma
                                • Extraction Method: Protein Precipitation
                                • Instrumentation: Waters Xevo TQMS
                                • No. Code: 1105

                                  High Throughput LDTD-MS/MS Quantification of 4 Immunosuppressive Drugs in Whole Blood

                                  • Partnership: None
                                  • Molecules: Sirolimus, Everolimus, Tacrolimus, Cytclosporin A
                                  • Matrix: Human Blood
                                  • Extraction Method: Protein Precipitation
                                  • Instrumentation: AB/Sciex Qtrap 5500
                                  • No. Code: 1301

                                    Solid-Phase Extraction of Clenbuterol in Plasma and analysis by LDTD-MS/MS

                                    • Partnership: SiliCycle
                                    • Molecules: Clenbuterol
                                    • Matrix: Human Plasma
                                    • Extraction Method: Solid Phase Extraction
                                    • Instrumentation: Thermo Vantage Mass Spec
                                    • No. Code: 1305
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