Laser Diode Thermal Desorption - Application Notes

Clinical

Measurement of drugs and their metabolites in biological fluids is the foundation of both therapeutic drug monitoring (TDM) and toxicology. Each discipline depends on accurate identification and quantification if the measurements are to be useful. Immunosuppressant testing, Vitamin D and testosterone are a few of the most common tests conducted.

Vitamin D testing is prevalent as well, and for good reason. According to the National Center for Health Statistics, as many as 36% of Americans are low in vitamin D levels, with 40% of infants and toddlers testing below the optimal blood threshold level.

Hematocrit effect: Does it influence the analysis of plasma samples ….

  • Partnership: --
  • Molecules:
  • Matrix: Blood
  • Extraction Method: Liquid-Liquid extraction of plasma, DBS card extract, DBS in tips extract
  • Instrumentation: LDTD
  • No. Code:
Download

Urine and serum Ultra-Rapid Analysis of Flakka (alpha-PVP) in 9 seconds per sample by LDTD-MS/MS

  • Partnership: Universite Laval
  • Molecules: Synthetic cathinone (Flakka)
  • Matrix: Urine and serum
  • Extraction Method: Liquid Liquid Extraction (LLE)
  • Instrumentation: SCIEX Qtrap 5500
  • No. Code:
Download

LDTD-MS/MS Method for Quantitative Analysis of Four Immunosuppressant Drugs in Whole Blood and Cost Analysis Comparison to LC-MS/MS

  • Partnership: ARUP Institute for Clinical and Experimental Pathology; Univ of Utah Health Sciences Center, Dept of Pathology
  • Molecules: Immunosuppressants
  • Matrix: Whole blood
  • Extraction Method: Solid phase extraction (SPE)
  • Instrumentation: SCIEX 5500
  • No. Code:
Download

Quantification of Tenoflovir and Emtricitabine in human plasma using high throughput LDTD-MS/MS

  • Partnership: Universite Laval
  • Molecules: Tenofovir, Emtricitabine
  • Matrix: Human plasma
  • Extraction Method: SCX SPE cartridges and quick derivation using TMPAH
  • Instrumentation: SCIEX 5500 QTRAP
  • No. Code:
Download

Ultra-Fast Quantification of Antidepressants in urine at 9 seconds per sample using LDTD-MS/MS

  • Partnership: Universite Laval
  • Molecules: 7 antidepressants
  • Matrix: Urine
  • Extraction Method: Liquid-Lquid Extraction (LLE)
  • Instrumentation: SCIEX 5500 QTRAP
  • No. Code:
Download

Meconium Targeted Drug Screening in 9 Seconds per Sample Using LDTD-MS/MS

  • Partnership: ARUP Institute for Clinical and Experimental Pathology (Utah, USA)
  • Molecules: 26 drugs of abuse - incl. amphetamine, MDMA, etc.
  • Matrix: Mecondium
  • Extraction Method: Liquid Liquid Extraction (LLE)
  • Instrumentation: SCIEX 5500 QTRAP
  • No. Code:
Download

Meconium Targeted Drug Screening in 9 Seconds per Sample Using LDTD-MS/MS

  • Partnership: ARUP Institute for Clinical & Experimental Pathology, and University of Utah, Dept of Pathology
  • Molecules: 26 drugs of abuse
  • Matrix: Meconium
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Sciex 5500 QTrap
  • No. Code:
Download

Ultra-Fast Quantitative Analysis of Immunosuppressants in Dried Blood Spots Using LDTD coupled to tandem Mass Spectrometry

  • Partnership: None
  • Molecules: Cyclosporin A, Tacrolimus, Sirolimus, Everolimus
  • Matrix: DBS
  • Extraction Method:
  • Instrumentation:
  • No. Code: n/a
Download

Targeted Screening for Drugs of Abuse using LDTD and Mass Spectrometry

  • Partnership: none
  • Molecules: Amphetamine, Methamphetamine, MDEA and MDMA
  • Matrix: Urine
  • Extraction Method: Liquid-liquid Extration (LLE)
  • Instrumentation: Sciex 5500 QTrap
  • No. Code:
Download

Fate of anti-inflammatory drug diclofenac in municipal wasterwater treatment plant: quantification using LDTD coupled with tandem mass spectrometry

  • Partnership: INRS-FTE University du Quebec (Quebec, Canada), C02 Solutions Inc. (Quebec, Canada), University of Nebraska-Lincoln (Lincoln, NE)
  • Molecules: Diclofenac
  • Matrix: Wastewater
  • Extraction Method: SPE using C 18 cartridges
  • Instrumentation: Thermo Vantage mass spectrometer
  • No. Code: 307
Download

Total cholesterol and HDL cross validation between high throughput LDTD-MS/MS method and reference enzymatic technique used in clinical laboratory

  • Partnership: n/a
  • Molecules: Cholesterol and HDL
  • Matrix: Serum
  • Extraction Method: Specific HDL separation, saponification reaction and LLE for cholesterol
  • Instrumentation:
  • No. Code: 329
Download

Determination of Testosterone in Serum by Automated Sample Preparation and Ultra-Fast LDTD-DMS-MS-MS in a Cross Validation Study with Real Patient Samples

  • Partnership: Tecan Group
  • Molecules: Testosterone
  • Matrix: Serum
  • Extraction Method:
  • Instrumentation: Sciex 5500 Qtrap with Selexion (DMS)
  • No. Code:
Download

HDL and Total Cholesterol Analysis by LDTD-MS/MS in 7 seconds per sample ….

  • Partnership: N/A
  • Molecules: Cholesterol
  • Matrix: Seum
  • Extraction Method: Saponification reaction and LLE
  • Instrumentation: Waters Xevo TQ MS
  • No. Code:
Download

Total cholestorol analysis in plasma at 7 seconds per sample using LDTD-MS/MS

  • Partnership: Universite Laval Quebec
  • Molecules: Cholestorol
  • Matrix: Plasma
  • Extraction Method: LLE
  • Instrumentation: Waters Xevo TQ
  • No. Code: THP411
Download

Method Validation of 12 Benzodiazepines by LDTD-MS/MS Analysis in 6 seconds per sample with correlative data from LC-MS/MS for 200 real patient urine samples

  • Partnership: n/a
  • Molecules: 12 benzodiazepines with similar chemical structures and molecular weight
  • Matrix: Human urine
  • Extraction Method: Sample hydrolysis, Solid phase extraction (SPE) and Liquid-liquid extraction (LLE)
  • Instrumentation: AB Sciex Qtrap 5500
  • No. Code: n/a
Download

Selectivity Enhancement in High Throughput Analysis of Testosterone

  • Partnership:
  • Molecules: Testosterone
  • Matrix:
  • Extraction Method: Liquid-liquid extraction
  • Instrumentation: AB Sciex Qtrap 5500 system with SelexION
  • No. Code: MP 49
Download

High-Throughput Analysis of Cocaine in Hair Samples using LDTD combined with Mass Spectrometry

  • Partnership: Omega Laboratories, Inc.
  • Molecules: Cocaine
  • Matrix: Hair
  • Extraction Method: Liquid-liquid extraction
  • Instrumentation: Thermo Vantage Mass spectrometer
  • No. Code:
Download

Fast and Selective Quantification of Testosterone in Plasma using LDTD-Qtrap 5500 SelexION System

  • Partnership: None
  • Molecules: Testosterone
  • Matrix: Human Plasma
  • Extraction Method: Liquid-Liquid
  • Instrumentation: AB Sciex Qtrap 5500 with SelexION
  • No. Code: 1220
Download

Confirmation of Cotinine in Human Plasma and analysis by LDTD–MS/MS

  • Partnership: None
  • Molecules: Cotinine
  • Matrix: Human Plasma
  • Extraction Method: Liquid-Liquid
  • Instrumentation: AbSciex TripleTOF 5600
  • No. Code: 1213
Download

LDTD-MS/MS Method Validation According to FDA Regulation

  • Partnership: None
  • Molecules: Dextromethorphan
  • Matrix: Human Plasma
  • Extraction Method: Protein Precipitation
  • Instrumentation: Waters Xevo TQMS
  • No. Code: 1105
Download

High Throughput LDTD-MS/MS Quantification of 4 immunosuppressive drugs in whole blood

  • Partnership: None
  • Molecules: Sirolimus, Everolimus, Tacrolimus, Cytclosporin A
  • Matrix: Human Blood
  • Extraction Method: Protein Precipitation
  • Instrumentation: AB/Sciex Qtrap 5500
  • No. Code: 1301
Download

Solid-Phase Extraction of Clenbuterol in Plasma and analysis by LDTD-MS/MS

  • Partnership: SiliCycle
  • Molecules: Clenbuterol
  • Matrix: Human Plasma
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: Thermo Vantage Mass Spec
  • No. Code: 1305
Download