Laser Diode Thermal Desorption - Application Notes

Toxicology

Toxicology tests (screens) are done to find the cause of life-threatening symptoms, determine drug use in the workplace, drug use with athletes and student-athletes (both professional and amateur), and other social settings or populations. Testing is often done in urine or saliva, but blood, hair and other matrices are used as well. Testing is done for prescription medicines, nonprescription medicines, vitamins, nutritional supplements, alcohol and illegal drugs, often using urine or saliva, but blood, hair and other matrices are used as well.

Dried Blood Spots in Tips Targeted Drug Screening in 9 seconds per sample using LDTD-MS/MS

  • Partnership: Universite Laval (Quebec, Canada)
  • Molecules:
  • Matrix: Dried Blood Spots
  • Extraction Method:
  • Instrumentation: SCIEX 5500 QTRAP
  • No. Code:
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Generic Extraction Method for screening of 8 drugs of abuse in Saliva with a quick turnaround analysis by LDTD-MS/MS

  • Partnership: Universite Laval (Quebec, Canada)
  • Molecules:
  • Matrix: Saliva
  • Extraction Method: Liquid-liquid extraction
  • Instrumentation: Shimadzu LCMS-8060
  • No. Code:
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Ultra-Rapid Analysis Method for Flakka (alpha-PVP), a Synthetic Cathinone Drug in Urine and Serum at 9 Seconds per Sample Using LDTD-MS/MS

  • Partnership: n/a
  • Molecules: alpha-PVP, a Synthetic Cathinone
  • Matrix: Urine and Serum
  • Extraction Method: Liquid-liquid extraction
  • Instrumentation: Sciex QTRAP 5500
  • No. Code: --
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Ultra-Fast Targeted Screening of 35 Drugs of Abuse in Urine at 9 Seconds per Sample Using SALLE Extraction and LDTD-MS/MS

  • Partnership: n/a
  • Molecules: Amphetamine, Cotinine, Methadone, EDDP, Oxycodone, Codeine, Hydrocodone, etc .
  • Matrix: Urine
  • Extraction Method: Generic SALLE
  • Instrumentation: Sciex QTRAP 5500
  • No. Code:
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Targeted Screening of Barbituarates drug in urine using High-throughput LDTD-MS/MS

  • Partnership: Universite Laval (Quebec, Canada)
  • Molecules: Barbituarates
  • Matrix: Urine
  • Extraction Method: LLE
  • Instrumentation: AB Sciex 5500 QTrap
  • No. Code: 204
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Automated Targeted Screening of Benzodiazepines in urine using LDTD-MS/MS at 400 samples per hour

  • Partnership: Universite Laval (Quebec, Canada)
  • Molecules: Benzodiazepines
  • Matrix: Urine
  • Extraction Method: Enzymatic hydrolysis followed by LLE
  • Instrumentation: AB Sciex 5500 QTrap
  • No. Code: 203
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Ultra high throughput analysis method of synthetic phenethylamines (25 I-NBOMe and 25B-NBOMe) in urine, saliva and serum by LDTD-MS/MS

  • Partnership: Universite Laval (Quebec, Canada)
  • Molecules: Synthetic phenethylamines
  • Matrix: Urine, saliva and serum
  • Extraction Method: LLE
  • Instrumentation: AB Sciex 5500 QTrap
  • No. Code: 181
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Ultra-fast Separation and Quantification of Isobaric barbituarates in serum using LDTD-MS/MS combined with differential mobility spectrometry

  • Partnership: n/a
  • Molecules: Barbiturates
  • Matrix: Serum
  • Extraction Method:
  • Instrumentation: AB Sciex 5500 QTrap
  • No. Code: Oral presentation by Sylvain Letarte, PhD
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Automated Targeted Screening of Benzodiazepines in Urine using LDTD-MS/MS at 400 Samples per Hour Rate

  • Partnership: n/a
  • Molecules: Benzodiazepines
  • Matrix: Urine
  • Extraction Method: LLE
  • Instrumentation: Sciex 5500 QTrap
  • No. Code:
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High Throughput Targeted Screening and Definitive Method for Barbituate Drugs in Urine

  • Partnership: n/a
  • Molecules: Barbituate
  • Matrix: Urine
  • Extraction Method: LLE
  • Instrumentation: Sciex 5500 QTrap
  • No. Code:
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2012 and 2013 Trends in Cannabimimetic Urine Drug Testing

  • Partnership: Aegis Sciences Corporation
  • Molecules: JWH-073, JWH-018, JWH-122, JWH-210, JWH-250, JWH-081, JWH-019, JWH-398, AM-2201, UR-144, MAM-2201
  • Matrix: Urine
  • Extraction Method: mixed mode SPE with elute with dichloromethane
  • Instrumentation: Screen with LDTD-MS/MS
  • No. Code: --
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ASMS 2010 LDTD-MS/MS Analysis of Chloroquine, Proguanil and Mefloquine in Human Urine

  • Partnership: Tandem Labs
  • Molecules: Chloroquine, Proguanil and Mefloquine
  • Matrix: Human Urine
  • Extraction Method:
  • Instrumentation:
  • No. Code: ASMS 2010
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ASMS 2008 High-Throughput screening and Quantification of Doping Agents in Urine Using LDTD-APCI-MS/MS

  • Partnership: INRS - Doping Control
  • Molecules: Prednisone Hydrochlorothiazide, Benzoylecgonine, Modafinil Acid
  • Matrix: Human Urine
  • Extraction Method: Liquid-Liquid Extraction (LLE)
  • Instrumentation: Thermo TSQ Quantum Ultra AM
  • No. Code: ThP-201
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SOFT-TIAFT 2011 Confirmation of Methadone and EDDP in Urine by LDTD

  • Partnership: Calloway Labs
  • Molecules: Metadone and EDDP
  • Matrix: Human Urine
  • Extraction Method: SPE
  • Instrumentation: AB Sciex API 4000
  • No. Code: SOFT-TIAFT 2011
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SOFT-TIAFT 2011 Confirmation of Propoxyphene and Norpropoxylene in Urine by LDTD

  • Partnership: Calloway Labs
  • Molecules: Propoxyphene and Norpropoxylene
  • Matrix: Urine
  • Extraction Method: SPE
  • Instrumentation: Agilent 6410 QQQ
  • No. Code: SOFT-TIAFT 2011
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High Throughput Analysis of Opiates in Hair Samples using LDTD coupled to MS

  • Partnership: Omega Labs (Ohio), UQTR (Canada)
  • Molecules: Opiates
  • Matrix: Hair
  • Extraction Method: SPE
  • Instrumentation: AB Sciex QTRAP 5500
  • No. Code: SOFT 2014
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Ultra-fast screening method for Drugs of Abuse in urine using simple sample preparation combined to LDTD-MS/MS

  • Partnership: n/a
  • Molecules: Various drugs of abuse: amphetamines, PCP, etc.
  • Matrix: Urine
  • Extraction Method: 4 different sample prep methods
  • Instrumentation: AB Sciex QTRAP 5500
  • No. Code: SOFT 2014
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Development of an ultra-rapid, high throughput analysis method of synthetic phenetylamines (25I-NBOMe and 25B-NBOMe) in urine, saliva and serum by LDTD

  • Partnership: n/a
  • Molecules: Synthetic phenethylamines (25I-NBOMe and 25B-NBOMe)
  • Matrix: Urine, saliva, serum
  • Extraction Method: LLE
  • Instrumentation: AB Sciex 5500 QTRAP
  • No. Code:
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Ultra-Fast Immunosuppressant Quantitation in whole blood by LDTD-MS/MS: 9 seconds sample-to-sample

  • Partnership: ARUP Labs, AB Sciex
  • Molecules: Tacrolimus, Sirolimus, Everolimus, Cydosporin A
  • Matrix: Whole blood
  • Extraction Method:
  • Instrumentation: QTRAP 5500 with SelexION
  • No. Code: TP #41
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Selective High-Throughput method for simultaneous analysis of 14 Benzodiazepines in Urine

  • Partnership:
  • Molecules: Benzodiazepines
  • Matrix: Urine
  • Extraction Method:
  • Instrumentation:
  • No. Code: ThP19-396
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ASMS 2012: New High-Throughput analysis method for volatile amines

  • Partnership:
  • Molecules: Amines
  • Matrix: Urine
  • Extraction Method: LLE with pH optimization
  • Instrumentation: Waters Xevo TQ-MS
  • No. Code: ThP19-411
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ASMS 2012: Fast K2/SPICE metabolite quantification using LDTD combined with High Resolution Mass Spectometry

  • Partnership:
  • Molecules: K2/Spice
  • Matrix: Urine
  • Extraction Method: Various
  • Instrumentation: AB Sciex Triple TOF 5600
  • No. Code: TP36-690
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High-Throughput Workflow for Midazolam and 1-Hydroxymidazolam Analysis in Human Plasma

  • Partnership: Northern Tier Research, Caliper Life Sciences
  • Molecules: Midazolam, I-Hydroxymidazolan
  • Matrix: Human Plasma
  • Extraction Method: SPE extraction method
  • Instrumentation:
  • No. Code: ThP-687
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LDTD High-Throughput Screening and Quantification of Doping Agents in Human Urine

  • Partnership: INRS- Doping Control
  • Molecules: Hydroxythiazide, Benzoylecgonine, and Prednisone
  • Matrix: Human urine
  • Extraction Method:
  • Instrumentation: Thermo Fisher TSQ Quantum Ultra AM mass spectrometer
  • No. Code: AN-0711
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Ultra Fast Analysis of 13 Benzodiazepines by LDTD-MS/MS cross validated with LC-MS/MS for 200 real urine samples

  • Partnership: N/A
  • Molecules: Benzodiazepines
  • Matrix: Urine
  • Extraction Method: LLE
  • Instrumentation: ABSciex APl5500 QTRAP
  • No. Code: MP284
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High-Throughput Analysis of Cocaine in Hair Samples using LDTD combined with Mass Spectrometry

  • Partnership: Omega Laboratories, Inc.
  • Molecules: Cocaine
  • Matrix: Hair
  • Extraction Method: Liquid-liquid extraction
  • Instrumentation: Thermo Vantage Mass spectrometer
  • No. Code:
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Validation of High-Throughput Analysis of THC in Oral Fluid Using LDTD combined with Mass Spectra

  • Partnership: OraSure Technologies
  • Molecules: Tetrahydrocannabinol (THC)
  • Matrix: Oral fluids
  • Extraction Method: Liquid-liquid extraction
  • Instrumentation: AB Sciex Qtrap 5500
  • No. Code:
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Butalbital, Secobarbital and Phenobarbital Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS

  • Partnership: Orasure Technologies
  • Molecules: Butalbital, Secobarbital, Phenobarbital
  • Matrix: Saliva
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Xevo TQMS Waters
  • No. Code: 1212
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Fentanyl Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS

  • Partnership: Orasure Technologies
  • Molecules: Fentanyl
  • Matrix: Saliva
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1207
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PCP Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS

  • Partnership: Orasure Technologies
  • Molecules: PCP
  • Matrix: Saliva
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1206
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Confirmation of Methadone and EDDP in Urine by Laser Diode Thermal Desorption (LDTD)

  • Partnership: Calloway Labs
  • Molecules: Methadone, EDDP
  • Matrix: Human Urine
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: Agilent 6410
  • No. Code: 1104
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Confirmation of Propoxyphene and Norpropoxyphene in Urine by Laser Diode Thermal Desorption (LDTD)

  • Partnership: Calloway Labs
  • Molecules: Propoxyphene, Norpropoxyphene
  • Matrix: Human Urine
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: AbSciex API 4000
  • No. Code: 1103
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LDTD High-Throughput Screening and Quantification of Doping Agents in Human Urine

  • Partnership: INRS-Doping Control
  • Molecules: Hydroxythiazide, Benzoylecgonine, Prednisone
  • Matrix: Human Urine
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Thermo TSQ Quantum Ultra AM
  • No. Code: 0711
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Tetrahydrocannabinol(THC) Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS

  • Partnership: Orasure Technologies
  • Molecules: Tetrahydrocannabinol (THC)
  • Matrix: Saliva
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1214
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Methadone Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS

  • Partnership: OraSure Technologies
  • Molecules: Methadone
  • Matrix: Saliva
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1205
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Solid-Phase Extraction of MDMA, MDA and MDEA in Urine and analysis by LDTD–MS/MS

  • Partnership: SiliCycle
  • Molecules: MDMA, MDA, MDEA
  • Matrix: Human Urine
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: AB Sciex TripleTOF 5600
  • No. Code: 1211
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Solid-Phase Extraction of Amphetamine and Methamphetamine in Urine and analysis by LDTD–MS/MS

  • Partnership: SilliCycle
  • Molecules: Amphetamine and Methamphetamine
  • Matrix: Human Urine
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1203
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Fast and Selective Quantification of Benzodiazepines un Urine using LDTD-TripleTOF™ 5600 System

  • Partnership: None
  • Molecules: 7-Aminoclonazepam, 7-aminoflunitrazepam, Chlordiazepoxide, Diazepam/Nordiazepam,Estazolam, Lorazepam, Clonazepam, OH-Alprazolam, OH-Ethylfluorazepam, OH-Midazolam, OH-Triazolam, Oxazepam, Temazepam
  • Matrix: Human Urine
  • Extraction Method: Liquid-Liquid
  • Instrumentation: AB Sciex TripleTOF 5600
  • No. Code: 1216
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Fast and Selective Quantification of Opiates in Urine using LDTD-TripleTOF™ 5600 System

  • Partnership: AbSciex
  • Molecules: Codeine, Morphine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone
  • Matrix: Human Urine
  • Extraction Method: Derivatization + Solid Phase Extraction
  • Instrumentation: AB Sciex Triple TOF 5600
  • No. Code: 1112
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Confirmation of Amphetamine, Methamphetamine, MDA, MDMA and MDEA in Urine via analysis by LDTD-MS/MS

  • Partnership: None
  • Molecules: Amphetamine, Methamphetamine, MDA, MDMA, MDEA
  • Matrix: Human Urine
  • Extraction Method: Liquid-Liquid
  • Instrumentation: AB Sciex Qtrap 5500
  • No. Code: 1309
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Solid-Phase Extraction of Clenbuterol in Plasma and analysis by LDTD-MS/MS

  • Partnership: SiliCycle
  • Molecules: Clenbuterol
  • Matrix: Human Plasma
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: Thermo Vantage Mass Spec
  • No. Code: 1305
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Confirmation of Methadone and 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP) in Urine and analysis by LDTD–MS/MS

  • Partnership: None
  • Molecules: Methadone, EDDP
  • Matrix: Human Urine
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1215
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Solid-Phase Extraction of Fentanyl and Norfentanyl in Urine and analysis by LDTD–MS/MS

  • Partnership: SiliCycle
  • Molecules: Fentanyl, Norfentanyl
  • Matrix: Human Urine
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1210
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Solid-Phase Extraction of Methadone and EDDP in Urine and analysis by LDTD-MS/MS

  • Partnership: SiliCycle
  • Molecules: Methadone, EDDP
  • Matrix: Human Urine
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1209
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Solid-Phase Extraction of PCP in Urine and analysis by LDTD-MS/MS

  • Partnership: SiliCycle
  • Molecules: PCP
  • Matrix: Human Urine
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1208
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Solid-Phase Extraction in Tip of Benzoylecgonine in Urine and analysis by LDTD-MS/MS

  • Partnership: Hummingbird
  • Molecules: Benzoylecgonine
  • Matrix: Human Urine
  • Extraction Method: Solid Phase Extraction
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1221
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Fast K2,SPICE analysis using LDTD-TripleTOF 5600

  • Partnership: AB Sciex
  • Molecules: JWH-018-OH, JWH-018-COOH, JWH-073-OH, JWH-073-COOH
  • Matrix: Human Urine
  • Extraction Method: Liquid-Liquid
  • Instrumentation: AB Sciex TripleTOF 5600
  • No. Code: PHAB_1108
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Amphetamine and Methamphetamine Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS

  • Partnership: Orasure Technologies
  • Molecules: Amphetamine Methamphetamine
  • Matrix: Saliva
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1204
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Cocaine Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS

  • Partnership: Orasure Technologies
  • Molecules: Cocaine
  • Matrix: Saliva
  • Extraction Method: Liquid-Liquid
  • Instrumentation: Thermo TSQ Vantage Triple Quadrupole
  • No. Code: 1202
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Fast and Selective screening of 34 drugs of abuse in urine Using LDTD-TripleTOFTM 5600

  • Partnership: AB/Sciex
  • Molecules: 7-aminiclonazepam, 7-aminoflunitrazepam, Amobarital, Butalbital, Chlordiazepoxide, Codeine, Diazepam/Nordiazepam, Estazolam, Fentanyl/Norfentanyl, JWH-018_OH, JWH-18COOH, JWH-073-OH, JWH-073-COOH, Lorazepam, Meperidine/Normeperdine, Methadone/EDDP, Morphine, OH-alprazolam, OH-Ethylflurazepam, OH-Midazolam, OH-Triazolam, Oxazepam, Oxycodone/Oxymorphone, Phenobarbital, Propoxyphene, Norpropoxyphene, Secobarbital, Temazepam, THC-COOH
  • Matrix: Human Urine
  • Extraction Method: Acid or Basic Liquid-Liquid
  • Instrumentation: AB/Sciex Triple TOF 5600
  • No. Code: PHAB_1110
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