It’s common to use LC-MS/MS for measurement of drugs and their metabolites. In some laboratories, LC-MS/MS has replaced GC/MS as the former has become the most versatile quantitative mass spectrometer available.
In today’s busy clinical lab, they’re beset by two, sometimes, conflicting requirements:
▪ Quality control
▪ High throughput
Being able to produce a large number of diagnostic tests without errors is the mandate, but it is not always so easy to achieve.
The focus on quality control, data integrity and speed of execution depends alot on analytical instrumentation automation.
LC-MS/MS is a good beginning, but may not be sufficient to handle the demands of a forward-looking and progressive clinical lab setting.
Liquid handlers, robotics, software and LC-MS/MS may not be sufficient
Over the last decade, pharmaceutical firms found High Throughput Screening (HTS) facilitates early elimination of unsuitable compounds. And while advanced technologies like automated liquid handlers, robotics, highly sophisticated analytical instrumentation, along with software help pump out an increasing number of tests, there are some labs that have found this to not be sufficient to handle the workload.
Automation with ultra-fast analysis is even better. Consider LDTD-MS/MS.
The beauty of the LDTD for clinical laboratories has its beginnings in the applications developed for the pharmaceutical and toxicology applications. HTS arrays are used for screening of different types of compound libraries, and the main goal is to accelerate drug discovery by screening large libraries at a rate that exceeds existing rates.
Just as LDTD has been applied in metabolite identification in HT assays concerning adsorption, distribution, metabolism and elimination of potential drugs, LDTD-MS/MS provides ultra-fast analysis in high throughput environments including clinical. Scores of methods have been developed with matrices including urine, blood, plasma and oral fluids, proving to be robust, versatile and economical.
Clinical settings doing any of the following may be particularly interested in LDTD/MS-MS:
- Compliance monitoring
- Drugs of abuse testing
- Pain medication monitoring
- Background screening
- Immunosuppressive drugs
To learn more, there’s plenty of app notes, posters and scientific papers including those produced by LDTD users at
- Overbrook Scientific Users
- Request your complementary copy of The 7 Most FAQ About LDTD and/or
- List of compounds and metabolites developed using LDTD-MS/MS through firstname.lastname@example.org, or 617-364-7683 .