TOXICOLOGY DOCUMENTS
Laser Diode Thermal Desorption Application Notes
Toxicology
Toxicology tests (screens) are done to find the cause of life-threatening symptoms, determine drug use in the workplace, drug use with athletes and student-athletes (both professional and amateur), and other social settings or populations. Testing is often done in urine or saliva, but blood, hair and other matrices are used as well. Testing is done for prescription medicines, non-prescription medicines, vitamins, nutritional supplements, and alcohol and illegal drugs.
Key Parameters for a Good Liquid Transfer to Lazwell Plates
KEYWORDS:
- Lazwell
- LDTD
- Liquid Transfer
Development of a Screening Method for 11-nor-9-carboxy-delta-tetrahydrocannabinol Drugs in Hair Using LDTD-MS3 at 8 Seconds per Sample
KEYWORDS:
- Drugs
- LDTD-MS3
High-Throughput Screening in Hair for Drugs: Screening of Drugs in Hair at 9 Seconds per Sample Using LUXON-MS/MS
KEYWORDS:
- High-throughput
- Hair
- Drugs
- Luxon-MS/MS
Analysis of Urine Biomarker for Alcohol Consumption: Screening of ETG in Urine at 9 Seconds per Sample Using LUXON-MS/MS
KEYWORDS:
- High-throughput
- Urine
- Luxon-MS/MS
SAMHSA Drug Panel Screening in Oral Fluid: Drug Screening in Oral Fluid at 8 Seconds per Sample Using SALLE method and LUXON - MS/MS
KEYWORDS:
- High-throughput
- Oral fluid
- Luxon-MS/MS
SAMHSA Drug Panel Screening in Urine: Drug Screening in Urine at 8 Seconds per Sample Using LUXON-MS/MS
KEYWORDS:
- High-throughput
- Urine
- Luxon-MS/MS
SAMHSA Drug Panel Screening in Oral Fluid: Drug Screening in Oral Fluid at 8 Seconds per Sample Using Oral-Eze® device and LUXON - MS/MS
KEYWORDS:
- High-throughput
- Oral fluid
- Luxon-MS/MS
Analysis of Urine Biomarker for Toluene, Xylene and Styrene Exposure: Biomarker Screening in Urine at 8 Seconds per Sample Using LUXON-MS/MS
- Partnership: N/A
- Compounds: Toluene, Xylene and Styrene
- Matrix: Urine
- Extraction Method:
- Instrumentation: Luxon-MS/MS
- No. Code: AN-2101
SAMHSA Drug Panel Screening in Oral Fluid: Drug Screening in Oral Fluid at 8 Seconds per Sample Using LUXON-MS/MS
- Partnership: None
- Molecules: N/A
- Matrix: Oral Fluid
- Extraction Method: Automated
- Instrumentation: Luxon-ms/ms
- No. Code: AN-2009
High-Throughput Screening in Hair for Drugs Using Luxon Ion Source® MS/MS System
- Partnership: n/a
- Molecules: Amphetamine, Morphine, Oxycodone, Codeine, Cocaine, THC, etc.
- Matrix: Hair
- Extraction Method:
- Instrumentation: API 5000 QTrap
- No. Code:1903
Dried Blood Spots in Tips Targeted Drug Screening in 9 seconds per Sample Using LDTD-MS/MS
- Partnership: Universite Laval (Quebec, Canada)
- Molecules:
- Matrix: Dried Blood Spots
- Extraction Method:
- Instrumentation: SCIEX 5500 QTRAP
- No. Code:
Urine LDTD Shotgun Screening: Drugs of Abuse in Urine at 9 Seconds Per Sample Using Dry and Dissolve Easy Preparation
- Partnership: n/a
- Molecules:Amphetamine, Cotinine, Methadone, EDDP, Oxycodone, Codeine, Hydrocodone, etc.
- Matrix: Urine
- Extraction Method: Dry and Dilute
- Instrumentation: Sciex 5500 QTrap
- No. Code:1901
Ultra-Rapid Analysis Method for Flakka (alpha-PVP), a Synthetic Cathinone Drug in Urine and Serum at 9 Seconds per Sample Using LDTD-MS/MS
- Partnership: n/a
- Molecules: alpha-PVP, a Synthetic Cathinone
- Matrix: Urine and Serum
- Extraction Method: Liquid-liquid extraction
- Instrumentation: Sciex QTRAP 5500
- No. Code: --
Generic Extraction Method for Screening of 8 drugs of Abuse in Saliva with a Quick Turnaround Analysis by LDTD-MS/MS
- Partnership: Universite Laval (Quebec, Canada)
- Molecules:
- Matrix: Saliva
- Extraction Method: Liquid-liquid extraction
- Instrumentation: Shimadzu LCMS-8060
- No. Code:
Targeted Screening of Barbiturates Drug in Urine Using High-Throughput LDTD-MS/MS
- Partnership: Universite Laval (Quebec, Canada)
- Molecules: Barbiturates
- Matrix: Urine
- Extraction Method: LLE
- Instrumentation: AB Sciex 5500 QTrap
- No. Code: 204
Ultra-Fast Targeted Screening of 35 Drugs of Abuse in Urine at 9 Seconds per Sample Using SALLE Extraction and LDTD-MS/MS
- Partnership: N/A
- Molecules: Amphetamine, Cotinine, Methadone, EDDP, Oxycodone, Codeine, Hydrocodone, etc.
- Matrix: Urine
- Extraction Method: Generic SALLE
- Instrumentation: Sciex QTRAP 5500
- No. Code:
Ultra High-Throughput Analysis Method of Synthetic Phenethylamines (25 I-NBOMe and 25B-NBOMe) in Urine, Saliva and Serum by LDTD-MS/MS
- Partnership: Universite Laval (Quebec, Canada)
- Molecules: Synthetic phenethylamines
- Matrix: Urine, saliva and serum
- Extraction Method: LLE
- Instrumentation: AB Sciex 5500 QTrap
- No. Code: 181
Automated Targeted Screening of Benzodiazepines in Urine Using LDTD-MS/MS at 400 Samples per Hour
- Partnership: Universite Laval (Quebec, Canada)
- Molecules: Benzodiazepines
- Matrix: Urine
- Extraction Method: Enzymatic hydrolysis followed by LLE
- Instrumentation: AB Sciex 5500 QTrap
- No. Code: 203
Automated Targeted Screening of Benzodiazepines in Urine Using LDTD-MS/MS at 400 Samples per Hour
- Partnership: Universite Laval (Quebec, Canada)
- Molecules: Benzodiazepines
- Matrix: Urine
- Extraction Method: Enzymatic hydrolysis followed by LLE
- Instrumentation: AB Sciex 5500 QTrap
- No. Code: 203
Ultra-fast Separation and Quantification of Isobaric Barbiturates in Serum Using LDTD-MS/MS Combined with Differential Mobility Spectrometry
- Partnership: N/A
- Molecules: Barbiturates
- Matrix: Serum
- Extraction Method:
- Instrumentation: AB Sciex 5500 QTrap
- No. Code: Oral presentation by Sylvain Letarte, PhD
2012 and 2013 Trends in Cannabimimetic Urine Drug Testing
- Partnership: Aegis Sciences Corporation
- Molecules: JWH-073, JWH-018, JWH-122, JWH-210, JWH-250, JWH-081, JWH-019, JWH-398, AM-2201, UR-144, MAM-2201
- Matrix: Urine
- Extraction Method: mixed mode SPE with elute with dichloromethane
- Instrumentation: Screen with LDTD-MS/MS
- No. Code:
High-Throughput Targeted Screening and Definitive Method for Barbiturate Drugs in Urine
- Partnership: n/a
- Molecules: Barbiturate
- Matrix: Urine
- Extraction Method: LLE
- Instrumentation: Sciex 5500 QTrap
- No. Code:
ASMS 2008 High-Throughput Screening and Quantification of Doping Agents in Urine Using LDTD-APCI-MS/MS
- Partnership: INRS - Doping Control
- Molecules: Prednisone Hydrochlorothiazide, Benzoylecgonine, Modafinil Acid
- Matrix: Human Urine
- Extraction Method: Liquid-Liquid Extraction (LLE)
- Instrumentation: Thermo TSQ Quantum Ultra AM
- No. Code: ThP-201
ASMS 2010 LDTD-MS/MS Analysis of Chloroquine, Proguanil and Mefloquine in Human Urine
- Partnership: Tandem Labs
- Molecules: Chloroquine, Proguanil and Mefloquine
- Matrix: Human Urine
- Extraction Method:
- Instrumentation:
- No. Code: ASMS 2010
SOFT-TIAFT 2011 Confirmation of Propoxyphene and Norpropoxylene in Urine by LDTD
- Partnership: Calloway Labs
- Molecules: Propoxyphene and Norpropoxylene
- Matrix: Urine
- Extraction Method: SPE
- Instrumentation: Agilent 6410 QQQ
- No. Code: SOFT-TIAFT 2011
SOFT-TIAFT 2011 Confirmation of Methadone and EDDP in Urine by LDTD
- Partnership: Calloway Labs
- Molecules: Metadone and EDDP
- Matrix: Human Urine
- Extraction Method: SPE
- Instrumentation: AB Sciex API 4000
- No. Code: SOFT-TIAFT 2011
Ultra-fast Screening Method for Drugs of Abuse in Urine Using Simple Sample Preparation Combined to LDTD-MS/MS
- Partnership: N/A
- Molecules: Various drugs of abuse: amphetamines, PCP, etc.
- Matrix: Urine
- Extraction Method: 4 different sample prep methods
- Instrumentation: AB Sciex QTRAP 5500
- No. Code: SOFT 2014
High-Throughput Analysis of Opiates in Hair Samples using LDTD Coupled to MS
- Partnership: Omega Labs (Ohio), UQTR (Canada)
- Molecules: Opiates
- Matrix: Hair
- Extraction Method: SPE
- Instrumentation: AB Sciex QTRAP 5500
- No. Code: SOFT 2014
Ultra-Fast Immunosuppressant Quantitation in Whole Blood by LDTD-MS/MS: 9 Seconds Sample-to-Sample
- Partnership: ARUP Labs, AB Sciex
- Molecules: Tacrolimus, Sirolimus, Everolimus, Cydosporin A
- Matrix: Whole blood
- Extraction Method:
- Instrumentation: QTRAP 5500 with SelexION
- No. Code: TP #41
Development of an Ultra-rapid, High-Throughput Analysis Method of Synthetic Phenethylamines (25I-NBOMe and 25B-NBOMe) in Urine, Saliva and Serum by LDTD
- Partnership: N/A
- Molecules: Synthetic phenethylamines (25I-NBOMe and 25B-NBOMe)
- Matrix: Urine, saliva, serum
- Extraction Method: LLE
- Instrumentation: AB Sciex 5500 QTRAP
- No. Code:
ASMS 2012: New High-Throughput Analysis Method for Volatile Amines
- Partnership:
- Molecules: Amines
- Matrix: Urine
- Extraction Method: LLE with pH optimization
- Instrumentation: Waters Xevo TQ-MS
- No. Code: ThP19-411
Selective High-Throughput Method for Simultaneous Analysis of 14 Benzodiazepines in Urine
- Partnership:
- Molecules: Benzodiazepines
- Matrix: Urine
- Extraction Method:
- Instrumentation:
- No. Code: ThP19-396
High-Throughput Workflow for Midazolam and 1-Hydroxymidazolam Analysis in Human Plasma
- Partnership: Northern Tier Research, Caliper Life Sciences
- Molecules: Midazolam, I-Hydroxymidazolan
- Matrix: Human Plasma
- Extraction Method: SPE extraction method
- Instrumentation:
- No. Code: ThP-687
ASMS 2012: Fast K2/SPICE Metabolite Quantification Using LDTD Combined with High Resolution Mass Spectrometry
- Partnership:
- Molecules: K2/Spice
- Matrix: Urine
- Extraction Method: Various
- Instrumentation: AB Sciex Triple TOF 5600
- No. Code: TP36-690
LDTD High-Throughput Screening and Quantification of Doping Agents in Human Urine
- Partnership: INRS- Doping Control
- Molecules: Hydroxythiazide, Benzoylecgonine, and Prednisone
- Matrix: Human urine
- Extraction Method:
- Instrumentation: Thermo Fisher TSQ Quantum Ultra AM mass spectrometer
- No. Code: AN-0711
Ultra-fast Analysis of 13 Benzodiazepines by LDTD-MS/MS Cross-Validated with LC-MS/MS for 200 Real Urine Samples
- Partnership: N/A
- Molecules: Benzodiazepines
- Matrix: Urine
- Extraction Method: LLE
- Instrumentation: ABSciex APl5500 QTRAP
- No. Code: MP284
High-Throughput Analysis of Cocaine in Hair Samples Using LDTD Combined with Mass Spectrometry
- Partnership: Omega Laboratories, Inc.
- Molecules: Cocaine
- Matrix: Hair
- Extraction Method: Liquid-liquid extraction
- Instrumentation: Thermo Vantage Mass spectrometer
- No. Code:
Validation of High-Throughput Analysis of THC in Oral Fluid Using LDTD Combined with Mass Spectra
- Partnership: OraSure Technologies
- Molecules: Tetrahydrocannabinol (THC)
- Matrix: Oral fluids
- Extraction Method: Liquid-liquid extraction
- Instrumentation: AB Sciex Qtrap 5500
- No. Code:
Butalbital, Secobarbital and Phenobarbital Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS
- Partnership: Orasure Technologies
- Molecules: Butalbital, Secobarbital, Phenobarbital
- Matrix: Saliva
- Extraction Method: Liquid-Liquid
- Instrumentation: Xevo TQMS Waters
- No. Code: 1212
Fentanyl Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS
- Partnership: Orasure Technologies
- Molecules: Fentanyl
- Matrix: Saliva
- Extraction Method: Liquid-Liquid
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1207
PCP Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS
- Partnership: Orasure Technologies
- Molecules: PCP
- Matrix: Saliva
- Extraction Method: Liquid-Liquid
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1206
Confirmation of Methadone and EDDP in Urine by Laser Diode Thermal Desorption (LDTD)
- Partnership: Calloway Labs
- Molecules: Methadone, EDDP
- Matrix: Human Urine
- Extraction Method: Solid Phase Extraction
- Instrumentation: Agilent 6410
- No. Code: 1104
Confirmation of Propoxyphene and Norpropoxyphene in Urine by Laser Diode Thermal Desorption (LDTD)
- Partnership: Calloway Labs
- Molecules: Propoxyphene, Norpropoxyphene
- Matrix: Human Urine
- Extraction Method: Solid Phase Extraction
- Instrumentation: AbSciex API 4000
- No. Code: 1103
LDTD High-Throughput Screening and Quantification of Doping Agents in Human Urine
- Partnership: INRS-Doping Control
- Molecules: Hydroxythiazide, Benzoylecgonine, Prednisone
- Matrix: Human Urine
- Extraction Method: Liquid-Liquid
- Instrumentation: Thermo TSQ Quantum Ultra AM
- No. Code: 0711
Tetrahydrocannabinol(THC) Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS
- Partnership: Orasure Technologies
- Molecules: Tetrahydrocannabinol (THC)
- Matrix: Saliva
- Extraction Method: Liquid-Liquid
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1214
Methadone Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS
- Partnership: OraSure Technologies
- Molecules: Methadone
- Matrix: Saliva
- Extraction Method: Liquid-Liquid
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1205
Solid-Phase Extraction of MDMA, MDA and MDEA in Urine and analysis by LDTD–MS/MS
- Partnership: SiliCycle
- Molecules: MDMA, MDA, MDEA
- Matrix: Human Urine
- Extraction Method: Solid Phase Extraction
- Instrumentation: AB Sciex TripleTOF 5600
- No. Code: 1211
Solid-Phase Extraction of Amphetamine and Methamphetamine in Urine and Analysis by LDTD–MS/MS
- Partnership: SilliCycle
- Molecules: Amphetamine and Methamphetamine
- Matrix: Human Urine
- Extraction Method: Solid Phase Extraction
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1203
Fast and Selective Quantification of Benzodiazepines in Urine Using LDTD-TripleTOF™ 5600 System
- Partnership: None
- Molecules: 7-Aminoclonazepam, 7-aminoflunitrazepam, Chlordiazepoxide, Diazepam/Nordiazepam,Estazolam, Lorazepam, Clonazepam, OH-Alprazolam, OH-Ethylfluorazepam, OH-Midazolam, OH-Triazolam, Oxazepam, Temazepam
- Matrix: Human Urine
- Extraction Method: Liquid-Liquid
- Instrumentation: AB Sciex TripleTOF 5600
- No. Code: 1216
Fast and Selective Quantification of Opiates in Urine Using LDTD-TripleTOF™ 5600 System
- Partnership: AbSciex
- Molecules: Codeine, Morphine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone
- Matrix: Human Urine
- Extraction Method: Derivatization + Solid Phase Extraction
- Instrumentation: AB Sciex Triple TOF 5600
- No. Code: 1112
Confirmation of Amphetamine, Methamphetamine, MDA, MDMA and MDEA in Urine via Analysis by LDTD-MS/MS
- Partnership: None
- Molecules: Amphetamine, Methamphetamine, MDA, MDMA, MDEA
- Matrix: Human Urine
- Extraction Method: Liquid-Liquid
- Instrumentation: AB Sciex Qtrap 5500
- No. Code: 1309
Solid-Phase Extraction of Clenbuterol in Plasma and Analysis by LDTD-MS/MS
- Partnership: SiliCycle
- Molecules: Clenbuterol
- Matrix: Human Plasma
- Extraction Method: Solid Phase Extraction
- Instrumentation: Thermo Vantage Mass Spec
- No. Code: 1305
Confirmation of Methadone and 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP) in Urine and Analysis by LDTD–MS/MS
- Partnership: None
- Molecules: Methadone, EDDP
- Matrix: Human Urine
- Extraction Method: Liquid-Liquid
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1215
Solid-Phase Extraction of Fentanyl and Norfentanyl in Urine and Analysis by LDTD–MS/MS
- Partnership: SiliCycle
- Molecules: Fentanyl, Norfentanyl
- Matrix: Human Urine
- Extraction Method: Solid Phase Extraction
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1210
Solid-Phase Extraction of Methadone and EDDP in Urine and Analysis by LDTD-MS/MS
- Partnership: SiliCycle
- Molecules: Methadone, EDDP
- Matrix: Human Urine
- Extraction Method: Solid Phase Extraction
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1209
Solid-Phase Extraction of PCP in Urine and Analysis by LDTD-MS/MS
- Partnership: SiliCycle
- Molecules: PCP
- Matrix: Human Urine
- Extraction Method: Solid Phase Extraction
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1208
Solid-Phase Extraction in Tip of Benzoylecgonine in Urine and Analysis by LDTD-MS/MS
- Partnership: Hummingbird
- Molecules: Benzoylecgonine
- Matrix: Human Urine
- Extraction Method: Solid Phase Extraction
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1221
Fast K2/SPICE Analysis Using LDTD-TripleTOF 5600
- Partnership: AB Sciex
- Molecules: JWH-018-OH, JWH-018-COOH, JWH-073-OH, JWH-073-COOH
- Matrix: Human Urine
- Extraction Method: Liquid-Liquid
- Instrumentation: AB Sciex TripleTOF 5600
- No. Code: PHAB_1108
Fast and Selective Screening of 34 drugs of Abuse in Urine Using LDTD-TripleTOFTM 5600
- Partnership: AB/Sciex
- Molecules: 7-aminiclonazepam, 7-aminoflunitrazepam, Amobarital, Butalbital, Chlordiazepoxide, Codeine, Diazepam/Nordiazepam, Estazolam, Fentanyl/Norfentanyl, JWH-018_OH, JWH-18COOH, JWH-073-OH, JWH-073-COOH, Lorazepam, Meperidine/Normeperdine, Methadone/EDDP, Morphine, OH-alprazolam, OH-Ethylflurazepam, OH-Midazolam, OH-Triazolam, Oxazepam, Oxycodone/Oxymorphone, Phenobarbital, Propoxyphene, Norpropoxyphene, Secobarbital, Temazepam, THC-COOH
- Matrix: Human Urine
- Extraction Method: Acid or Basic Liquid-Liquid
- Instrumentation: AB/Sciex Triple TOF 5600
- No. Code: PHAB_1110
Cocaine Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS
- Partnership: Orasure Technologies
- Molecules: Cocaine
- Matrix: Saliva
- Extraction Method: Liquid-Liquid
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1202
Amphetamine and Methamphetamine Confirmation in Oral Fluids by Laser Diode Thermal Desorption (LDTD) – MS/MS
- Partnership: Orasure Technologies
- Molecules: Amphetamine Methamphetamine
- Matrix: Saliva
- Extraction Method: Liquid-Liquid
- Instrumentation: Thermo TSQ Vantage Triple Quadrupole
- No. Code: 1204
