HPLC SUPPORT
HPLC Support Information
A collection of informative and useful articles related to the common challenges associated with the use and support of HPLC within the laboratory.

The appearance of your HPLC’s baseline noise is one of the most useful indicators of its overall performance and cleanliness. The ratio of the detector’s signal response to a specified standard when compared to the background signal variation is known as the “signal to noise ratio.”
When you notice abnormalities in the baseline noise, it can be attributed to a number of different factors.

Highly sensitive lab instruments need to be serviced and maintained appropriately and effectively. Avoiding contamination can help prevent signal suppression, reduce background noise, minimize adduct formation, and elevate spectrum complexity. In order to achieve the most accurate results, contamination prevention is crucial.

To ensure a product is safe and meets its intended use, method validation, and instrument qualifications are necessary Qualifications (IQ/OQ/PQ) provide a systematic approach to confirming that each instrument is proven to be accurate and precise. This process should be both scientifically strict, but also straightforward and repeatable.
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